Proteomics

Dataset Information

10

APE1 INTERACTOME - Architecture of The Human Ape1 Interactome Defines Novel Cancers Signatures


ABSTRACT: The present work aimed at defining the association of the APE1-protein-protein interactions network in modulating its role in tumor progression and chemoresistance through proteomic and bionformatic analyses

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo sapiens  

TISSUE(S): Tissue Not Applicable To Dataset

DISEASE(S): Not Available

SUBMITTER: CHIARA D'AMBROSIO  

LAB HEAD: Andrea Scaloni

PROVIDER: PXD013368 | Pride | 2020-01-16

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
CCE_APE_.msf Msf
CCE_APE_1.raw Raw
CCE_APE_10.raw Raw
CCE_APE_10BIS.raw Raw
CCE_APE_11.raw Raw
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Publications

Architecture of The Human Ape1 Interactome Defines Novel Cancers Signatures.

Ayyildiz Dilara D   Antoniali Giulia G   D'Ambrosio Chiara C   Mangiapane Giovanna G   Dalla Emiliano E   Scaloni Andrea A   Tell Gianluca G   Piazza Silvano S  

Scientific reports 20200108 1


APE1 is essential in cancer cells due to its central role in the Base Excision Repair pathway of DNA lesions and in the transcriptional regulation of genes involved in tumor progression/chemoresistance. Indeed, APE1 overexpression correlates with chemoresistance in more aggressive cancers, and APE1 protein-protein interactions (PPIs) specifically modulate different protein functions in cancer cells. Although important, a detailed investigation on the nature and function of protein interactors re  ...[more]

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