Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Drosophila Melanogaster (fruit Fly)
TISSUE(S): Cell Culture
SUBMITTER: Marzia Munafo
LAB HEAD: Gregory J Hannon
PROVIDER: PXD013417 | Pride | 2019-04-18
REPOSITORIES: Pride
Munafò Marzia M Manelli Vera V Falconio Federica A FA Sawle Ashley A Kneuss Emma E Eastwood Evelyn L EL Seah Jun Wen Eugene JWE Czech Benjamin B Hannon Gregory J GJ
Genes & development 20190523 13-14
The Piwi-interacting RNA (piRNA) pathway is a small RNA-based immune system that silences mobile genetic elements in animal germlines. piRNA biogenesis requires a specialized machinery that converts long single-stranded precursors into small RNAs of ∼25-nucleotides in length. This process involves factors that operate in two different subcellular compartments: the nuage/Yb body and mitochondria. How these two sites communicate to achieve accurate substrate selection and efficient processing rema ...[more]