Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Kidney
DISEASE(S): Papillary Renal Cell Carcinoma
SUBMITTER: Ayham Alahmad
LAB HEAD: David Meierhofer
PROVIDER: PXD013523 | Pride | 2019-09-06
REPOSITORIES: Pride
Al Ahmad Ayham A Paffrath Vanessa V Clima Rosanna R Busch Jonas Felix JF Rabien Anja A Kilic Ergin E Villegas Sonia S Timmermann Bernd B Attimonelli Marcella M Jung Klaus K Meierhofer David D
Cancers 20190903 9
Papillary renal cell carcinoma (pRCC) is a malignant kidney cancer with a prevalence of 7-20% of all renal tumors. Proteome and metabolome profiles of 19 pRCC and patient-matched healthy kidney controls were used to elucidate the regulation of metabolic pathways and the underlying molecular mechanisms. Glutathione (GSH), a main reactive oxygen species (ROS) scavenger, was highly increased and can be regarded as a new hallmark in this malignancy. Isotope tracing of pRCC derived cell lines reveale ...[more]