Proteomics

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CEH-60/PBX regulates vitellogenesis and cuticle formation through interaction with UNC-62/MEIS in Caenorhabditis elegans

ABSTRACT: The onset of sexual maturity involves dramatic changes in physiology and gene expression in many animals. A textbook example is the production of enormous amounts of yolk proteins destined for the nascent oocytes, termed vitellogenesis. We previously identified the rapidly evolving PBC-class Hox-cofactor CEH-60/PBX as necessary for abundant vit transcription in C. elegans. Differential proteomics data shows that all vitellogenin proteins are indeed drastically downregulated in ceh-60 mutant animals and suggest an additional role for CEH-60’s involvement cuticle structure, innate immunity and stress response.

INSTRUMENT(S):

ORGANISM(S): Caenorhabditis Elegans

TISSUE(S): Whole Body

SUBMITTER: Pieter Van de Walle  

LAB HEAD: Liesbet Temmerman

PROVIDER: PXD013584 | Pride | 2019-09-25

REPOSITORIES: Pride

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Action DRS
CE_Leuven_tmt_ongefrationeerd_1.raw Raw
CE_Leuven_tmt_ongefrationeerd_2.raw Raw
CE_tmt1_fractie1.raw Raw
CE_tmt1_fractie10.raw Raw
CE_tmt1_fractie2.raw Raw
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Publications

CEH-60/PBX regulates vitellogenesis and cuticle permeability through intestinal interaction with UNC-62/MEIS in Caenorhabditis elegans.

Van de Walle Pieter P   Geens Ellen E   Baggerman Geert G   José Naranjo-Galindo Francisco F   Askjaer Peter P   Schoofs Liliane L   Temmerman Liesbet L  

PLoS biology 20191101 11

The onset of sexual maturity involves dramatic changes in physiology and gene expression in many animals. These include abundant yolk protein production in egg-laying species, an energetically costly process under extensive transcriptional control. Here, we used the model organism Caenorhabditis elegans to provide evidence for the spatiotemporally defined interaction of two evolutionarily conserved transcription factors, CEH-60/PBX and UNC-62/MEIS, acting as a gateway to yolk protein production.  ...[more]

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