Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Blood Serum
DISEASE(S): Celiac Disease
SUBMITTER: Rasmus Iversen
LAB HEAD: Ludvig M. Sollid
PROVIDER: PXD013777 | Pride | 2019-07-09
REPOSITORIES: Pride
Proceedings of the National Academy of Sciences of the United States of America 20190708 30
B cells play important roles in autoimmune diseases through autoantibody production, cytokine secretion, or antigen presentation to T cells. In most cases, the contribution of B cells as antigen-presenting cells is not well understood. We have studied the autoantibody response against the enzyme transglutaminase 2 (TG2) in celiac disease patients by generating recombinant antibodies from single gut plasma cells reactive with discrete antigen domains and by undertaking proteomic analysis of anti- ...[more]