Proteomics

Dataset Information

32

Proteomic analysis of antigen-specific serum and gut antibodies in celiac disease patients


ABSTRACT: Comparison of serum and gut antibodies against two major antigens in celiac disease patients, the autoantigen transglutaminase 2 (TG2) and a deamidated gluten peptide (DGP) from food. The antigen-specific antibodies were affinity-purified from isolated total IgA of serum or gut biopsy secretions or from whole serum samples. Individual clonotypes could be identified among the purified antibodies based on matching to a database of IgH sequences obtained from antigen-specific gut plasma cells of the same patients.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo sapiens  

SUBMITTER: Ludvig M. Sollid  

PROVIDER: MSV000081328 | Massive | Fri Jul 14 01:59:00 BST 2017

SECONDARY ACCESSION(S): PXD007047

REPOSITORIES: MassIVE

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