Role of Ssd1 in modulating protein abundance in aneuploid wild yeast

ABSTRACT: We discovered that wild yeast strains can tolerate extra chromosomes, a condition known as aneuploidy, whereas well-studied laboratory strains cannot. Understanding why some cells can tolerate aneuploidy and others cannot could have far-reaching impact, as for example, 85% of solid tumors are aneuploidy and often benefit from extra chromosomes, and thus identifying mechanisms of aneuploidy sensitization could have therapeutic applications.

INSTRUMENT(S):

ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)

SUBMITTER: Evgenia Shishkova  

LAB HEAD: Joshua Coon

PROVIDER: PXD013847 | Pride | 2020-01-17

REPOSITORIES: Pride