Role of Ssd1 in modulating protein abundance in aneuploid wild yeast
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: 
Evgenia Shishkova
LAB HEAD: Joshua Coon
PROVIDER: PXD013847 | Pride | 2020-01-17
REPOSITORIES: Pride
Publications
The genetic basis of aneuploidy tolerance in wild yeast.
Hose James J Escalante Leah E LE Clowers Katie J KJ Dutcher H Auguste HA Robinson DeElegant D Bouriakov Venera V Coon Joshua J JJ Shishkova Evgenia E Gasch Audrey P AP
eLife 20200107
Aneuploidy is highly detrimental during development yet common in cancers and pathogenic fungi - what gives rise to differences in aneuploidy tolerance remains unclear. We previously showed that wild isolates of <i>Saccharomyces cerevisiae</i> tolerate chromosome amplification while laboratory strains used as a model for aneuploid syndromes do not. Here, we mapped the genetic basis to Ssd1, an RNA-binding translational regulator that is functional in wild aneuploids but defective in laboratory s ...[more]
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