Role of GATA-2 -77 enhancer in murine blood progenitor cells

ABSTRACT: We discovered enhancers that control GATA-2 expression during mouse development and in adult and generated mutant mouse strains that lack these enhancers, and these mice have very specific and important phenotypes that revealed GATA-2 mechanisms to control stem and progenitor cell transitions. In this study we aim to determine what proteins are under control of the GATA-2 -77 enhancer in a pool of heterogeneous blood progenitor cells with the specific focus on Socs2 expression.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Blood Cell, Primary Cell

SUBMITTER: Evgenia Shishkova  

LAB HEAD: Joshua Coon

PROVIDER: PXD013855 | Pride | 2020-06-05

REPOSITORIES: Pride