Comparative integrated omics analysis of the Hfq regulon in Bordetella pertussis

ABSTRACT: This study represents the first attempt to characterize the RNA chaperone Hfq regulon in bacterial pathogen using an integrative omics approach. Gene expression profiles were analyzed by RNA-seq and protein amounts in cell-associated and cell-free fractions were determined by LC-MS/MS technique. Comparative analysis of transcriptomic and proteomic data revealed solid correlation considering the role of Hfq in post-transcriptional control of gene expression. Importantly, our study confirms and further enlightens the role of Hfq in pathogenicity of B. pertussis.

INSTRUMENT(S):

ORGANISM(S): Bordetella Pertussis (strain Tohama I / Atcc Baa-589 / Nctc 13251)

SUBMITTER: Denisa Petrackova  

LAB HEAD: Branislav Vecerek

PROVIDER: PXD013953 | Pride | 2019-07-02

REPOSITORIES: Pride