Proteomics

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Proteomic analysis of Mycobacterium tuberculosis induced by rifampicim

ABSTRACT: Rifampicin plays an important role during tuberculosis treatment, which historically contributed for shortening therapy; however, rifampicin resistance has been the intersection for the definition of multi (MDR-TB) and extensively (XDR-TB) resistant outcomes. A key aspect which has contributed for investigations of drug action/resistance is the understanding of the dynamic genome expression, as that analyzed by Proteomics. Proteins from the reference strain, Mycobacterium tuberculosis H37Rv were extracted after 12, 24 and 48 hours over rifampicin challenge at the minimal inhibitory concentration (0.03 μg•mL-1) and identified by LC-MS.

INSTRUMENT(S): impact II

ORGANISM(S): Mycobacterium Tuberculosis H37rv

SUBMITTER: Jean Eduardo Meneguello  

LAB HEAD: Paula Aline Zanetti Campanerut-Sá

PROVIDER: PXD014177 | Pride | 2021-05-04

REPOSITORIES: Pride

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Rifampicin plays an important role during the treatment of tuberculosis, which makes it to be recommended throughout the regimen. The molecular target for rifampicin activity and resistance is the bacterial RNA polymerase coded by rpoB. However, it has been observed that Mycobacterium tuberculosis could use different metabolic pathways contributing to drug activity/resistance. In this sense, Proteomics analysis has been a key aspect towards the understanding of the dynamic genome expression trig  ...[more]

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