Proteomics

Dataset Information

4

Serum protein profile in LPS-induced mice model by two-dimensional LC-MS/MS


ABSTRACT: Serum is an ideal source of biomarkers because of easy accessibility, noninvasiveness, and rapid response to disease. Given that the different clinical manifestation between early phase and late phase of sepsis, the change of serum proteins profile during different phase of sepsis can give insight into predictor for early diagnosis of sepsis. In this study, differential serum proteins were screened in mice treated with lipopolysaccharide (LPS) for 2 h, 24 h and controls using free-labeling coupled with two-dimensional liquid chromatography and tandem mass spectrometry (2D LC-MS/MS) technique.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus musculus  

TISSUE(S): Blood Serum

DISEASE(S): Not Available

SUBMITTER: Chunxia Wang  

LAB HEAD: Chunxia Wang

PROVIDER: PXD014259 | Pride | 2020-05-26

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
WCX_1704055_C1.raw Raw
WCX_1704055_C2.raw Raw
WCX_1704055_C3.raw Raw
WCX_1704055_L24_1.raw Raw
WCX_1704055_L24_2.raw Raw
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Publications

Apolipoprotein A-V Is a Novel Diagnostic and Prognostic Predictor in Pediatric Patients with Sepsis: A Prospective Pilot Study in PICU.

Wang Chunxia C   Cui Yun Y   Miao Huijie H   Xiong Xi X   Dou Jiaying J   Shao Lujing L   Tang Xiaomeng X   Zhang Yucai Y  

Mediators of inflammation 20200113


<h4>Background</h4>Sepsis induces the release of lipid mediators, which control both lipid metabolism and inflammation. However, the role of serum apolipoprotein A-V (ApoA5) in sepsis is poorly understood in pediatric patients.<h4>Methods</h4>ApoA5 was screened from serum proteomics profile in lipopolysaccharide- (LPS-) treated mice for 2 h, 24 h, and controls. Then, we conducted a prospective pilot study, and patients with sepsis admitted to a pediatric intensive care unit (PICU) were enrolled  ...[more]

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