Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
DISEASE(S): Alzheimer's Disease
SUBMITTER: Allan Stensballe
LAB HEAD: Allan Stensballe
PROVIDER: PXD014274 | Pride | 2021-03-25
REPOSITORIES: Pride
Bastrup Joakim J Kastaniegaard Kenneth K Asuni Ayodeji A AA Volbracht Christiane C Stensballe Allan A
Journal of Alzheimer's disease : JAD 20200101 1
Amyloid plaques are one of the hallmarks of Alzheimer's disease (AD). The main constituent of amyloid plaques is amyloid-β peptides, but a complex interplay of other infiltrating proteins also co-localizes. We hypothesized that proteomic analysis could reveal differences between amyloid plaques and adjacent control tissue in the transgenic mouse model of AD (APPPS1-21) and in similar regions from non-transgenic littermates. Our microproteomic strategy included isolation of regions of interest by ...[more]