Ontology highlight
ABSTRACT:
INSTRUMENT(S): Synapt MS
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: John R. Engen
LAB HEAD: John R. Engen
PROVIDER: PXD014348 | Pride | 2019-12-03
REPOSITORIES: Pride
Wang Jianchuan J Su Yang Y Iacob Roxana E RE Engen John R JR Springer Timothy A TA
Nature communications 20191202 1
Integrin αVβ8, which like αVβ6 functions to activate TGF-βs, is atypical. Its β8 subunit binds to a distinctive cytoskeleton adaptor and does not exhibit large changes in conformation upon binding to ligand. Here, crystal structures, hydrogen-deuterium exchange dynamics, and affinity measurements on mutants are used to compare αVβ8 and αVβ6. Lack of a binding site for one of three βI domain divalent cations and a unique β6-α7 loop conformation in β8 facilitate movements of the α1 and α1' helices ...[more]