Ontology highlight
ABSTRACT:
INSTRUMENT(S): Synapt MS
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: John R. Engen
LAB HEAD: John R. Engen
PROVIDER: PXD016059 | Pride | 2020-06-17
REPOSITORIES: Pride
Korshavn Kyle J KJ Wales Thomas E TE Bird Gregory H GH Engen John R JR Walensky Loren D LD
Nature structural & molecular biology 20200713 9
Apoptosis is regulated by BCL-2 family proteins. Anti-apoptotic members suppress cell death by deploying a surface groove to capture the critical BH3 α-helix of pro-apoptotic members. Cancer cells hijack this mechanism by overexpressing anti-apoptotic BCL-2 family proteins to enforce cellular immortality. We previously identified and harnessed a unique cysteine (C55) in the groove of anti-apoptotic BFL-1 to selectively neutralize its oncogenic activity using a covalent stapled-peptide inhibitor. ...[more]