Proteomics

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Human Globus Pallidus (GP) from Non-Hispanic Whites and African Americans with and without Alzheimer's disease LC-MS3


ABSTRACT: This study examined global proteomic changes in postmortem globus pallidus (GP) tissue from Non-Hispanic Whites and African American individuals who were cognitively normal or had Alzheimer's disease using LC-MS3 on an Orbitrap Fusion Lumos. Proteins were quantified in the LC-MS3 experiments using Tandem Mass Tags (TMT)10plex.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Vibrio natriegens NBRC 15636 = ATCC 14048 = DSM 759   Naja mandalayensis   Mycobacterium marinum ATCC BAA-535   Salmo salar   Cyclotella cryptica   Medicago truncatula var. truncatula   Schizosaccharomyces pombe 927   Hepatitis E virus type 1   hybrid   Ovis aries   Bradyrhizobium diazoefficiens USDA 110   Acanthoscurria gomesiana   Schizophyllum commune H4-8   Teleogryllus oceanicus   Shigella dysenteriae   Physcomitrium patens   Syntrophomonas wolfei   Schistosoma mansoni   Sinorhizobium meliloti BL225C   Chenopodium quinoa   Mycolicibacterium smegmatis MC2 155   Paucilactobacillus suebicus   Rhizobium sp. Leaf68   Pseudomonas aeruginosa PAO1   Bacillus cytotoxicus NVH 391-98   Glia   Trypanosoma brucei   Xenopus laevis   Hordeum vulgare   Mucilaginibacter   Human alphaherpesvirus 1   rhizosphere soil bacteria ensemble   Oncorhynchus tshawytscha   Aedes aegypti aegypti   Noccaea caerulescens   Lactococcus lactis subsp. cremoris MG1363   Canis lupus x Canis lupus familiaris   [Candida] glabrata   Mycoplasma pneumoniae M129   Acidithiobacillus ferrooxidans ATCC 53993   Fasciola hepatica   Tetrahymena thermophila   Cladocopium goreaui   Enterobacter cloacae   Streptomyces avidinii   Durusdinium trenchii   Euzebya tangerina   Trypanosoma   Influenza A virus (H1N1)   Staphylococcus aureus   Thermochaetoides thermophila   Mycoplasma gallisepticum S6   Olavius algarvensis Gamma 3 endosymbiont   Trypanosoma cruzi   Oryctolagus cuniculus   Archaea   Chromatiales bacterium OalgGamma1   Paracoccus denitrificans PD1222   Calicophoron daubneyi   Faecalibacterium prausnitzii   Halobacterium salinarum   Sorangium cellulosum So ce56   Dentex dentex   Synechococcus phage syn9   Coronavirus PREDICT CoV-2   Eukaryota   Helianthus annuus   Acinetobacter baumannii AB307-0294   Pachysolen tannophilus NRRL Y-2460   Oreochromis mossambicus   Mesocricetus auratus   Phytophthora pisi   Legionella pneumophila subsp. pneumophila str. Philadelphia 1   Trypanosoma cruzi strain Esmeraldo   Viruses   Populus trichocarpa   Macaca mulatta   Homo sapiens subsp. 'Denisova'   Klebsiella pneumoniae   Allexis   Lens culinaris   Dialister   Penaeus vannamei   Olavius algarvensis   Bicyclus anynana   Geobacter sulfurreducens   Bothrops neuwiedi   Mylodon darwinii   Lysiphlebus fabarum   Thermochaetoides thermophila DSM 1495   Escherichia coli O157:H7 str. TW14359   Quercus suber   Quercus ilex   Schizosaccharomyces pombe OY26   Acinetobacter baumannii   Malassezia sympodialis ATCC 42132   Plasmodium yoelii yoelii   Shigella sonnei 53G   Schizosaccharomyces pombe DM3650   Pseudotsuga menziesii var. menziesii   Nelumbo nucifera   Drosophila melanogaster   Streptococcus equi subsp. equi 4047   Naja ashei   Globicatella sanguinis   Clostridioides difficile 630   Streptococcus thermophilus LMD-9   Heloderma suspectum suspectum   Plasmodium sp. pBT9   Burkholderia sp. 2332   Salmonella enterica subsp. enterica serovar Typhimurium str. SDT1291   Human immunodeficiency virus   Human alphaherpesvirus 1 strain 17   Thalassiosira cf. oceanica   Daphnia magna   Acinetobacter baumannii ACICU   Gammarus fossarum   Rhodopseudomonas palustris   Acanthoscurria geniculata   Schizosaccharomyces pombe 972h-   Carica papaya   Leishmania mexicana   unclassified Marseilleviridae   Cleome angustifolia   Giardia intestinalis   Lentinus crinitus   Naja naja   Taenia hydatigena   Pedobacter sp.   Candida albicans   Francisella tularensis   Beauveria bassiana ARSEF 2860   Eulimnogammarus cyaneus   Pyricularia oryzae B157   Toxoplasma gondii type III   Lithobius forficatus   Sphingomonas sp. Leaf257   Apis mellifera ligustica   Lactococcus phage   Tarenaya hassleriana   Angiostrongylus cantonensis   Sus scrofa   Piaractus mesopotamicus   Candidatus Pelagibacter ubique   Pseudomonas stutzeri   Bothrops leucurus   Echinococcus granulosus   Oryza sativa   Blumeria hordei DH14   Phytophthora capsici LT1534   Ursus arctos arctos   Pseudomonas pseudoalcaligenes CECT 5344   Betaproteobacteria bacterium RIFCSPLOWO2_02_64_14   Bacillus subtilis subsp. subtilis str. 168   Clavibacter michiganensis subsp. nebraskensis NCPPB 2581   Mycobacteroides abscessus   Phytophthora capsici   Cervus nippon nippon   Sus scrofa domesticus   Melioribacter roseus P3M-2   Pyrococcus furiosus   Bovine leukemia virus   Anas platyrhynchos   Candidatus Thioglobus autotrophicus   Flavobacterium columnare   Spirometra erinaceieuropaei   Trichoderma sp. 1 YW-2011   Sarcoptes scabiei   Equus caballus   uncultured Phormidium sp.   Streptococcus pyogenes ABC020006030   Cryptochiton stelleri   Gynandropsis gynandra   Podospora anserina S mat+   Paramecium tetraurelia   Human herpesvirus 5 strain AD169   Burkholderia cenocepacia K56-2Valvano   Brugia malayi   Candidatus Nitrospira inopinata   Moraxella catarrhalis   Bradyrhizobium japonicum   Acinetobacter baumannii ATCC 19606 = CIP 70.34 = JCM 6841   Candidatus Accumulibacter phosphatis   Quercus robur   Human herpesvirus 2 strain 186   Dioscorea alata   Rhizophagus irregularis   Olavius algarvensis sulfate-reducing endosymbiont   Zea mays   Bordetella pertussis Tohama I   Quercus petraea   Crithidia fasciculata   Aspergillus flavus NRRL3357   Lingula anatina   Cupriavidus metallidurans   Listeria monocytogenes EGD-e   Anopheles culicifacies B   Bacteroides caccae   Francisella tularensis subsp. holarctica FSC200   Acinetobacter baumannii D1279779   Ophrys x arachnitiformis subsp. archipelagi   Brachyspiraceae   Colinus virginianus   Bartonella quintana   Acanthamoeba castellanii   Desulfovibrio sp. G11   Trichoderma harzianum CBS 226.95   Mariprofundus ferrooxydans   Lacticaseibacillus rhamnosus GG   Ficus carica   Aspergillus nidulans TN02A3   Strigamia maritima   Neurospora crassa   Brassica oleracea var. italica   Pteropus alecto   Mycobacterium tuberculosis M24   Listeria phage A118   Ensifer adhaerens   Actinomycetia   Saccharum hybrid cultivar   Oryza sativa Indica Group   Amaranthus tricolor   Paracoccidioides brasiliensis Pb18   Ctenopharyngodon idella   Struthio camelus   Synechocystis sp. PCC 6803   Rhizobium cf. leguminosarum   Deltaproteobacteria bacterium RIFCSPLOWO2_12_FULL_50_11   Vitis   environmental samples   Chlorella sp. SAG 211-18   Bacillus mycoides NBRC 101238 = DSM 11821   Coxiella burnetii RSA 493   Lagomorpha   Hydra vulgaris   Pogonomyrmex rugosus   unclassified Candidatus Omnitrophica   Elaeis guineensis   Catalpa fargesii   Synechococcus cyanophage syn   Priestia megaterium DSM 319   mixed culture metagenome   Mycobacterium tuberculosis SP22   Phytophthora sojae   Anopheles stephensi   Burkholderia pseudomallei 1026b   Dictyostelium discoideum AX4   Streptococcus pneumoniae TIGR4   Onchocerca volvulus   Ustilago maydis   Capsicum annuum var. annuum   Russula atropurpurea   Manica rubida   Larimichthys crocea   Pyricularia oryzae   Scolopendra morsitans   Galloanserae   Olavius algarvensis Delta 1 endosymbiont   Thalassiosira pseudonana CCMP1335   Capsicum annuum   Burkholderia ubonensis MSMB22   Tradescantia spathacea   Dasypogon diadema   Tapirus terrestris   Cyanophora paradoxa   Caenorhabditis elegans   Luteibacter   Ricinus communis   Oncorhynchus mykiss   Chlamydomonas reinhardtii   Ascaris suum   Fragaria x ananassa   prokaryotic environmental samples   Enterococcus mundtii CRL35   Bartonella quintana JK 31   Sedum plumbizincicola   Solanum tuberosum   Synechocystis sp. PCC 6803 substr. Kazusa   Tuber aestivum   Bos taurus   Francisella tularensis subsp. holarctica LVS   Klebsiella variicola At-22   Spirochaeta sp. ELBA   Aspergillus flavus   Thermoplasma acidophilum DSM 1728   Olavius algarvensis Gamma 1 endosymbiont   Cricetulus griseus   Streptococcus agalactiae FSL S3-026   metagenomes   Physcomitrella   Entamoeba histolytica   Brassica oleracea var. gemmifera   Panicum virgatum   Burkholderia cenocepacia   Francisella tularensis subsp. holarctica   Aves   Medicago truncatula   Corynebacterium glutamicum ATCC 13032   Vipera berus berus   Ganoderma lingzhi   Gammarus pulex   Clostridioides difficile ATCC 43255   Crassostrea gigas   Fraxinus mandshurica   Phytophthora infestans   Oreochromis niloticus niloticus   Roseburia   Gorilla gorilla   Bursaphelenchus xylophilus   Pseudomonas aeruginosa PA14   Human immunodeficiency virus 1   Herpes simplex virus unknown type   Bothrops moojeni   Emiliania   Aerococcus urinae NBRC 15544 = CCUG 36881   Mycoplasma pneumoniae M129-B7   Trichoderma reesei RUT C-30   Dendroaspis angusticeps   Steinernema carpocapsae   Pan troglodytes   Apostichopus japonicus   Strigomonas culicis   Ictidomys tridecemlineatus   Saccharomyces cerevisiae W303   Lactobacillus   Brassica napus   Pyrococcus abyssi   Muvirus mu   environmental samples   Ruminiclostridium cellulolyticum H10   Glycine max   Histomonas meleagridis   Tuber albidum   Cupiennius salei   Helicobacter pylori J99   Pseudomonas syringae   Malus domestica   Streptococcus pneumoniae SP14-BS69   Arachis hypogaea   Daphnia pulex   Dinoroseobacter shibae DFL 12 = DSM 16493   Helicobacter pylori 26695   Human alphaherpesvirus 1 strain KOS   Latilactobacillus curvatus   Granulicatella adiacens ATCC 49175   Aspergillus niger NRRL3   Stenotrophomonas maltophilia   Citrus maxima   human metagenome   Peniophora incarnata   Pseudomonas aeruginosa   Novosphingobium nitrogenifigens   soil bacterium TS1114R   Apis mellifera   Vicia faba   Daktulosphaira vitifoliae   [Ruminococcus] gnavus   Sophora alopecuroides   Boehmeria nivea   Leishmania braziliensis MHOM/BR/75/M2904   Taeniopygia guttata   Tuber melanosporum Mel28   Strawberry leafy fruit phytoplasma   Planococcus halocryophilus Or1   Brucella abortus   Bacillus subtilis subsp. spizizenii ATCC 6633 = JCM 2499   Arabidopsis thaliana   Beta vulgaris subsp. vulgaris   Trypanosoma brucei brucei TREU927   Siphoviridae   Amphibalanus amphitrite   Pseudomonas fluorescens SBW25   Brucella melitensis   Spondylus gaederopus   Enterococcus faecalis   Populus tremula x Populus alba   Vibrio cholerae O1 biovar El Tor str. N16961   Citrus sinensis   Staphylococcus haemolyticus   Scophthalmus maximus   Nematostella vectensis   Labeo rohita   Potentilla saundersiana   Heterosigma akashiwo   Haptophyta   Cercopithecidae   Felis catus   Hyalella azteca   environmental samples   Hippopotamus amphibius   Canis lupus familiaris   Bacteria   Medicago sativa   Parhyale hawaiensis   Theobroma cacao   Ictalurid herpesvirus 1   Rattus norvegicus   Mus musculus   Thermococcus gammatolerans EJ3   Mytilus edulis   Cyclopes didactylus   Trichechus manatus   Lactobacillus johnsonii N6.2   Trifolium pratense subsp. pratense   Bacillus subtilis   Mycolicibacterium smegmatis   Staphylococcus sp. 1   Armoracia rusticana   Bacillus pseudomycoides DSM 12442   Riptortus pedestris   Desulfovibrio ferrophilus   Campylobacter jejuni   Mycobacterium tuberculosis SP13   Flavobacterium sp. 316   Toxoplasma gondii   Bacillus mycoides DSM 2048   Cryptococcus neoformans var. grubii H99W   Pectobacterium carotovorum   Ceratopteris richardii   Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821   Olavius algarvensis Delta 4 endosymbiont   Plasmodium knowlesi strain H   Scheffersomyces stipitis   Octopodiformes   Oryctolagus cuniculus cuniculus   Synechococcus elongatus   Mycobacterium tuberculosis SP1   albimanus section   Rheum palmatum   Cryptococcus neoformans var. grubii H99   Escherichia coli O157:H7   Clostridium phage c-st   Phaseolus vulgaris   Chlorella vulgaris   Vibrio parahaemolyticus   Dioscorea oppositifolia   Tequatrovirus T4   Schizosaccharomyces pombe   Euprymna scolopes   Cytomegalovirus   Catenibacterium   Cervus elaphus elaphus   Riftia pachyptila   Trichoderma reesei QM9414   Saccostrea glomerata   Oryza sativa Japonica Group   Citrobacter rodentium   Plasmodium falciparum   Bothrops brazili   Giardia intestinalis assemblage A   Macaca fascicularis   Paramoeba perurans   Pyricularia oryzae P131   Mollivirus sibericum   Zymomonas mobilis   Crassostrea hongkongensis   Hebomoia glaucippe   gut metagenome   Chlamydia trachomatis 434/Bu   Mycobacterium tuberculosis SP7   Parasynechococcus marenigrum WH 8102   Capsaspora owczarzaki   Ophrys garganica   Palaemonetes sp. common grass shrimp associated circular virus   Rattus rattus   Latrodectus hesperus   Clostridium butyricum E4 str. BoNT E BL5262   Puccinellia tenuiflora   Solanum lycopersicum   Saccharopolyspora erythraea   Fusarium graminearum GZ3639   Aspergillus niger   Sphingobium chlorophenolicum   Leishmania donovani Ld 2001   Picea likiangensis var. rubescens   Leishmania major   Microcystis aeruginosa   Bacillus thuringiensis serovar berliner ATCC 10792   Granulicella sp.   Gallus gallus   Cavia porcellus   Acipenser transmontanus   Ostreococcus tauri   Gammarus roeselii   Candida tropicalis   Clostridioides difficile R20291   Camelus dromedarius   Bombyx mori   Mycoplasmopsis agalactiae   Oryctolagus sp. 'Rabbit_OD'   Triticum aestivum   Taenia solium   Borreliella burgdorferi B31   Leishmania donovani   Equus asinus   Homo   Capra hircus   Oryzias latipes   unidentified   Brassica oleracea var. botrytis   Giardia lamblia ATCC 50803   Drosophila   Entamoeba histolytica HM-1:IMSS-A   Nicotiana benthamiana   biofilm metagenome   Orycteropus afer   Dictyostelium discoideum   Severe acute respiratory syndrome coronavirus 2   Bubalus bubalis   Chlorocebus aethiops   Streptococcus dysgalactiae subsp. equisimilis SK1249   Exiguobacterium sp. SH31   Piper nigrum   Vitis riparia   Naja sagittifera   Synechococcus phage S-SSM7   Morchella importuna   Bothrops cotiara   Selaginella moellendorffii   Alteromonadales   Aggregatibacter actinomycetemcomitans   Mengo virus   Trichomonas gallinae   Cecropia peltata   anaerobic digester metagenome   Mycobacterium tuberculosis   Mycobacterium tuberculosis H37Rv   Epstein-barr virus strain p3hr-1   Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344   Vibrio anguillarum   Candidatus Endoriftia persephone   Marchantia polymorpha subsp. ruderalis   Acyrthosiphon pisum   Strongylocentrotus purpuratus   Haemophilus influenzae   Oryctolagus cuniculus algirus   Botrytis cinerea   Apteronotus leptorhynchus   Acinetobacter sp. PM-14   Listeria monocytogenes   Callinectes sapidus   Candidatus Accumulibacter   Aspergillus aff. niger A2   Toxoplasma gondii ME49   Emiliania huxleyi   Candida albicans SC5314   Streptococcus pneumoniae D39   Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10   Kluyveromyces marxianus   Leishmania major strain Friedlin   Pseudomonas aeruginosa PAO1H2O   Escherichia coli   Butyrivibrio fibrisolvens   Photobacterium profundum SS9   Rhodococcus jostii RHA1   Streptomyces coelicolor A3(2)   Salmo sp.   Dendroaspis polylepis polylepis   Bothrops insularis   Anopheles culicifacies A   Brucella   Pseudomonas putida BIRD-1   Channa striata   Trypanosoma brucei brucei   Bodo saltans   Bothrops jararacussu   Passiflora edulis   Chlorocebus sabaeus   Mustela putorius furo   Campylobacter fetus subsp. fetus 82-40   Klebsiella pneumoniae JH1   Hendra virus horse/Australia/Hendra/1994   Leishmania infantum JPCM5   Delonix regia   Ophrys sphegodes   Bacillus toyonensis BCT-7112   Paenibacillus sp.   Austrolebias   Lactococcus lactis subsp. cremoris UC509.9   Gossypium hirsutum   Lotus japonicus   Danio rerio   Bacillus cereus ATCC 14579   Eremothecium gossypii   Bemisia tabaci   Escherichia coli O157:NM   Bothrops jararaca   Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044   Pseudomonas putida F1   Craterostigmus tasmanianus   Olavius algarvensis spirochete endosymbiont   Botrytis cinerea B05.10   Bombus terrestris audax   Sorghum bicolor   Shigella flexneri 2a str. 2457T   Mycobacterium tuberculosis SP10   Saccharomyces cerevisiae EC1118   Sciuridae   Ruminiclostridium papyrosolvens DSM 2782   Dirofilaria immitis   Nicotiana tabacum   Meleagris gallopavo   Mycobacterium avium subsp. paratuberculosis K-10   Neisseria meningitidis MC58   uncultured marine microorganism   Heterorhabditis megidis   Coprococcus eutactus   Streptococcus pneumoniae R6   Clostridium saccharoperbutylacetonicum   Vitis vinifera   Coffea eugenioides   Streptococcus pyogenes   Coffea arabica   Streptomyces coelicolor   Tuber magnatum   Coffea canephora   Clostridium autoethanogenum   Picea abies   Deinococcus radiodurans R1   Tropilaelaps mercedesae   Xanthomonas oryzae pv. oryzae PXO99A   Nephila clavipes   Pseudomonas putida KT2440   Fraxinus nigra   Alternaria tomato   (Vitis vinifera x Vitis berlandieri) x Vitis berlandieri   Tuber indicum   Chlamydia trachomatis D/UW-3/CX   Desulforamulus reducens MI-1   Plasmodium falciparum 3D7   Saccharomyces cerevisiae   Avena strigosa   Populus yunnanensis   Scutigera coleoptrata   Homo sapiens  

TISSUE(S): Brain

DISEASE(S): Alzheimer's Disease

SUBMITTER: Kaitlyn Stepler  

LAB HEAD: Renã A.S. Robinson

PROVIDER: PXD014371 | Pride | 2020-10-19

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
GP_Batch1_Frac10_TR1_Redo.msf Msf
GP_Batch1_Frac10_TR1_Redo.raw Raw
GP_Batch1_Frac10_TR2_Redo.msf Msf
GP_Batch1_Frac10_TR2_Redo.raw Raw
GP_Batch1_Frac11_TR1.msf Msf
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Publications

Inclusion of African American/Black adults in a pilot brain proteomics study of Alzheimer's disease.

Stepler Kaitlyn E KE   Mahoney Emily R ER   Kofler Julia J   Hohman Timothy J TJ   Lopez Oscar L OL   Robinson Renã A S RAS  

Neurobiology of disease 20201010


Alzheimer's disease (AD) disproportionately affects certain racial and ethnic subgroups, such as African American/Black and Hispanic adults. Genetic, comorbid, and socioeconomic risk factors contribute to this disparity; however, the molecular contributions have been largely unexplored. Herein, we conducted a pilot proteomics study of postmortem brains from African American/Black and non-Hispanic White adults neuropathologically diagnosed with AD compared to closely-matched cognitively normal in  ...[more]

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