Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite, Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Neuroblast
SUBMITTER: Gereon Poschmann
LAB HEAD: Gereon Poschmann
PROVIDER: PXD014381 | Pride | 2020-03-30
REPOSITORIES: Pride
Brenig Katrin K Grube Leonie L Schwarzländer Markus M Köhrer Karl K Stühler Kai K Poschmann Gereon G
Journal of proteome research 20200403 5
The initial phases of neuronal differentiation are key to neuronal function. A particularly informative model to study these initial phases are retinoic acid-stimulated SH-SY5Y cells. Although these progressions are associated with redox-sensitive processes, it is largely undefined how the cellular proteome underpins redox dynamics and the management of reactive oxygen species. Here, we map the global cysteine-based redox landscape of SH-SY5Y cells using quantitative redox proteomics. We find ev ...[more]