Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Jolene Diedrich
LAB HEAD: Alan Saghatelian
PROVIDER: PXD014890 | Pride | 2019-11-12
REPOSITORIES: Pride
Chu Qian Q Martinez Thomas F TF Novak Sammy Weiser SW Donaldson Cynthia J CJ Tan Dan D Vaughan Joan M JM Chang Tina T Diedrich Jolene K JK Andrade Leo L Kim Andrew A Zhang Tong T Manor Uri U Saghatelian Alan A
Nature communications 20191025 1
Cellular homeostasis relies on having dedicated and coordinated responses to a variety of stresses. The accumulation of unfolded proteins in the endoplasmic reticulum (ER) is a common stress that triggers a conserved pathway called the unfolded protein response (UPR) that mitigates damage, and dysregulation of UPR underlies several debilitating diseases. Here, we discover that a previously uncharacterized 54-amino acid microprotein PIGBOS regulates UPR. PIGBOS localizes to the mitochondrial oute ...[more]