SILAC of HepG2 or HepAD38 cell lines with HBV

ABSTRACT: Hepatitis B Virus constitutes a major threat to global public health by infecting hepatocytes, initiating and driving the progress to end-stage liver disease and liver cancer. Curing treatment for HBV infection is yet unavailable, mainly due to unmet gaps in current understanding of HBV-host interaction. Here, multi-omics interrogations were conducted to generate the first landscape of HBV-induced global changes in host transcriptome, translatome and proteome, which identified multiple translatomic events that HBV orchestrated to remodel host proteostasis networks and afford micro-environments essential for HBV proliferation and persistence.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Hepatocyte, Cell Culture

DISEASE(S): Mixed Disorder As Reaction To Stress

SUBMITTER: Menghuan Zhang  

LAB HEAD: Ronggui Hu

PROVIDER: PXD014908 | Pride | 2021-03-06

REPOSITORIES: Pride