Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Permanent Cell Line Cell
DISEASE(S): Amyotrophic Lateral Sclerosis
SUBMITTER: Mona Radwan
LAB HEAD: Prof. Danny Hatters
PROVIDER: PXD015180 | Pride | 2020-02-25
REPOSITORIES: Pride
Radwan Mona M Ang Ching-Seng CS Ormsby Angelique R AR Cox Dezerae D Daly James C JC Reid Gavin E GE Hatters Danny M DM
Molecular & cellular proteomics : MCP 20200221 4
<i>C9ORF72</i>-associated Motor Neuron Disease patients feature abnormal expression of 5 dipeptide repeat (DPR) polymers. Here we used quantitative proteomics in a mouse neuronal-like cell line (Neuro2a) to demonstrate that the Arg residues in the most toxic DPRS, PR and GR, leads to a promiscuous binding to the proteome compared with a relative sparse binding of the more inert AP and GA. Notable targets included ribosomal proteins, translation initiation factors and translation elongation facto ...[more]