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Collagen induced arthritis plasma proteomic analysis

ABSTRACT: The aim of the project is to analyze the plasma proteomic profile of an animal model of arthritis (Collagen Induced Arthritis; CIA) in response to different treatments. For this, plasma samples from mice under five different treatments were analyzed (N=6 per group): Vehicle, CIA, CIA + Δ9-THCA-A (20 mg / kg), CIA + Δ9-THCA-A (20 mg / kg) + T0070907 (5 mg / kg) and CIA + Δ9-THCA-A (20 mg / kg) + SR141716A (5 mg / kg).

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Blood Plasma

DISEASE(S): Arthritis

SUBMITTER: Martin Garrido-Rodríguez

LAB HEAD: Eduardo Munoz

PROVIDER: PXD015274 | Pride | 2020-09-18

REPOSITORIES: Pride

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Δ<sup>9</sup> -Tetrahydrocannabinolic acid alleviates collagen-induced arthritis: Role of PPARγ and CB<sub>1</sub> receptors.

Palomares Belén B Garrido-Rodriguez Martín M Gonzalo-Consuegra Claudia C Gómez-Cañas María M Saen-Oon Suwipa S Soliva Robert R Collado Juan A JA Fernández-Ruiz Javier J Morello Gaetano G Calzado Marco A MA Appendino Giovanni G Muñoz Eduardo E

British journal of pharmacology 20200708 17

<h4>Background and purpose</h4>Δ<sup>9</sup> -Tetrahydrocannabinolic acid (Δ<sup>9</sup> -THCA-A), the precursor of Δ<sup>9</sup> -THC, is a non-psychotropic phytocannabinoid that shows PPARγ agonist activity. Here, we investigated the ability of Δ<sup>9</sup> -THCA-A to modulate the classic cannabinoid CB<sub>1</sub> and CB<sub>2</sub> receptors and evaluated its anti-arthritis activity in vitro and in vivo.<h4>Experimental approach</h4>Cannabinoid receptors binding and intrinsic activity, as w ...[more]

PMID: 32510591

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