Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Rattus Norvegicus (rat)
SUBMITTER: Natalie Krahmer
LAB HEAD: Carmine Settembre
PROVIDER: PXD015331 | Pride | 2020-07-15
REPOSITORIES: Pride
The EMBO journal 20200727 17
Lysosomal degradation of the endoplasmic reticulum (ER) via autophagy (ER-phagy) is emerging as a critical regulator of cell homeostasis and function. The recent identification of ER-phagy receptors has shed light on the molecular mechanisms underlining this process. However, the signaling pathways regulating ER-phagy in response to cellular needs are still largely unknown. We found that the nutrient responsive transcription factors TFEB and TFE3-master regulators of lysosomal biogenesis and aut ...[more]