Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos, TripleTOF 5600
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Jingzi Zhang
LAB HEAD: Qiming Sun
PROVIDER: PXD016661 | Pride | 2020-01-09
REPOSITORIES: Pride
The EMBO journal 20200113 5
Degradation of endoplasmic reticulum (ER) by selective autophagy (ER-phagy) is crucial for ER homeostasis. However, it remains unclear how ER scission is regulated for subsequent autophagosomal sequestration and lysosomal degradation. Here, we show that oligomerization of ER-phagy receptor FAM134B (also referred to as reticulophagy regulator 1 or RETREG1) through its reticulon-homology domain is required for membrane fragmentation in vitro and ER-phagy in vivo. Under ER-stress conditions, activa ...[more]