Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Keratinocyte
SUBMITTER: Marko Fonovic
LAB HEAD: Marko Fonovic
PROVIDER: PXD015679 | Pride | 2020-04-28
REPOSITORIES: Pride
Frontiers in microbiology 20200428
<i>Porphyromonas gingivalis</i>, the main etiologic agent of periodontitis, secretes cysteine proteases named gingipains. HRgpA and RgpB gingipains have Arg-specificity, while Kgp gingipain is Lys-specific. Together they can cleave an array of proteins and importantly contribute to the development of periodontitis. In this study we focused on gingipain-exerted proteolysis at the cell surface of human gingival epithelial cells [telomerase immortalized gingival keratinocytes (TIGK)] in order to be ...[more]