Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
SUBMITTER: Xiaoling Gao
LAB HEAD: Xiaoling Gao
PROVIDER: PXD016040 | Pride | 2020-01-09
REPOSITORIES: Pride
Wu Yu Y Wei Zhenhong Z Li Yonghong Y Wei Chaojun C Li Yuanting Y Cheng Pengfei P Xu Hui H Li Zhenhao Z Guo Rui R Qi Xiaoming X Jia Jing J Jia Yanjuan Y Wang Wanxia W Gao Xiaoling X
Frontiers in neuroscience 20191217
Hypothalamic dysfunction is a key pathological factor in inflammation-associated depression. In the present study, isobaric tags for relative-absolute quantitation (iTRAQ) combined with mass spectrometry and gas chromatography-mass spectrometry (GC-MS) were employed to detect the proteomes and metabolomes in the hypothalamus of the lipopolysaccharide (LPS)-induced depression mouse, respectively. A total of 187 proteins and 27 metabolites were differentially expressed compared with the control gr ...[more]