Structural diversity of toxins contained within the venom of the funnel web spider Hadronyche infensa.
Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 5600
ORGANISM(S): Hadronyche Infensa
TISSUE(S): Venom
SUBMITTER: 
Eivind Undheim
LAB HEAD: Eivind Undheim, University of Queensland
PROVIDER: PXD016886 | Pride | 2020-05-11
REPOSITORIES: Pride
Publications
Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene.
Pineda Sandy S SS Chin Yanni K-Y YK Undheim Eivind A B EAB Senff Sebastian S Mobli Mehdi M Dauly Claire C Escoubas Pierre P Nicholson Graham M GM Kaas Quentin Q Guo Shaodong S Herzig Volker V Mattick John S JS King Glenn F GF
Proceedings of the National Academy of Sciences of the United States of America 20200512 21
Spiders are one of the most successful venomous animals, with more than 48,000 described species. Most spider venoms are dominated by cysteine-rich peptides with a diverse range of pharmacological activities. Some spider venoms contain thousands of unique peptides, but little is known about the mechanisms used to generate such complex chemical arsenals. We used an integrated transcriptomic, proteomic, and structural biology approach to demonstrate that the lethal Australian funnel-web spider pro ...[more]
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