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Human BRS3 receptor activation LC-MSMS

ABSTRACT: Bombesin-like receptor 3 (BRS3), an orphan G protein–coupled receptor (GPCR), plays important roles in our biological system while the exact mechanisms behind are less known. To get insights of biological effects on BRS3 activation, we utilized quantitative proteomics approach to explore the dynamic protein profiling during its stimulus. At different time points after stimulation, the protein profiling in HEK 293 cells with overexpressed BRS3 (HEK 293-BRS3) were analyzed by nano-LC−MS/MS.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

SUBMITTER: lijie dong

LAB HEAD: Hua Xiao

PROVIDER: PXD017104 | Pride | 2020-02-25

REPOSITORIES: Pride

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			Action	DRS
	12B_1.raw	Raw
	12B_2.raw	Raw
	12B_3.raw	Raw
	12C_1.raw	Raw
	12C_2.raw	Raw

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Publications

Proteomics Analysis of Cellular BRS3 Receptor Activation Reveals Potential Mechanism for Signal Transduction and Cell Proliferation.

Dong Lijie L Zhang Baohui B Wu Lehao L Shang Zhi Z Liu Sha S Jiang Xiaoteng X Wang Huiyu H Fan Liuyin L Zhang Yan Y Xiao Hua H

Journal of proteome research 20200305 4

Bombesin-like receptor 3 (BRS3), an orphan G protein-coupled receptor (GPCR), plays important roles in our biological system while the exact mechanisms behind it are less known. To get insights of the biological effects upon BRS3 activation, we utilized quantitative proteomics approach to explore the dynamic protein profiling during the stimulation by its ligand. At different time points after stimulation with BRS3 surrogate agonist, the protein profiling in BRS3 overexpressed HEK 293 cells BRS3 ...[more]

PMID: 32091899

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