Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Drosophila Melanogaster (fruit Fly)
SUBMITTER: Alessandro Scacchetti
LAB HEAD: Peter B. Becker
PROVIDER: PXD017729 | Pride | 2020-05-27
REPOSITORIES: Pride
Scacchetti Alessandro A Schauer Tamas T Reim Alexander A Apostolou Zivkos Z Campos Sparr Aline A Krause Silke S Heun Patrick P Wierer Michael M Becker Peter B PB
eLife 20200520
Histone acetylation and deposition of H2A.Z variant are integral aspects of active transcription. In <i>Drosophila</i>, the single DOMINO chromatin regulator complex is thought to combine both activities <i>via</i> an unknown mechanism. Here we show that alternative isoforms of the DOMINO nucleosome remodeling ATPase, DOM-A and DOM-B, directly specify two distinct multi-subunit complexes. Both complexes are necessary for transcriptional regulation but through different mechanisms. The DOM-B comp ...[more]