Ontology highlight
ABSTRACT:
INSTRUMENT(S): Synapt MS
ORGANISM(S): Myxococcus Xanthus Dk 1622
SUBMITTER: Wieland Steinchen
LAB HEAD: Gert Bange
PROVIDER: PXD018028 | Pride | 2020-04-16
REPOSITORIES: Pride
Nature communications 20200414 1
Cyclic di-GMP (c-di-GMP) is a second messenger that modulates multiple responses to environmental and cellular signals in bacteria. Here we identify CdbA, a DNA-binding protein of the ribbon-helix-helix family that binds c-di-GMP in Myxococcus xanthus. CdbA is essential for viability, and its depletion causes defects in chromosome organization and segregation leading to a block in cell division. The protein binds to the M. xanthus genome at multiple sites, with moderate sequence specificity; how ...[more]