Proteomics

Dataset Information

Analysis of histone PTMs in nascent chromatin in new and old histones upon DNA damage (CAL353, CAL358) using the NCC-SILAC approach

ABSTRACT: Dynamic recycling and de novo deposition of histones are fundamental for chromatin restoration. Histone post-translational modifications (PTMs) are assumed to have a causal role in establishing distinct chromatin structures. However, it remains unknown how specific histone PTMs are regulated at broken replication fork. To get better insight into histone PTMs during DNA damage response, we combined NCC (Nascent chromatin capture) with SILAC-MS for identification of histone PTMs at replication forks upon CPT (camptothecin).

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell Of Cervix

SUBMITTER: Ignasi Forne  

LAB HEAD: Prof. Anja Groth

PROVIDER: PXD018220 | Pride | 2021-01-18

REPOSITORIES: Pride

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CAL353_H4_d3Ac_MS1_MS2y5_20191122.sky Other
CAL353_H4_d3Ac_MS1_MS2y5_20191122.sky.view Other
CAL353_H4_d3Ac_MS1_MS2y5_20191122.skyd Other
CAL358_H4_d3Ac_MS1_MS2y5_20191122.sky Other
CAL358_H4_d3Ac_MS1_MS2y5_20191122.sky.view Other
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