Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cerebrospinal Fluid
DISEASE(S): Medulloblastoma
SUBMITTER: Christopher Gerner
LAB HEAD: Christopher Gerner
PROVIDER: PXD018226 | Pride | 2020-06-01
REPOSITORIES: Pride
Reichl Bernd B Niederstaetter Laura L Boegl Thomas T Neuditschko Benjamin B Bileck Andrea A Gojo Johannes J Buchberger Wolfgang W Peyrl Andreas A Gerner Christopher C
Cancers 20200526 6
Molecular classification of medulloblastoma (MB) is well-established and reflects the cell origin and biological properties of tumor cells. However, limited data is available regarding the MB tumor microenvironment. Here, we present a mass spectrometry-based multi-omics pilot study of cerebrospinal fluid (CSF) from recurrent MB patients. A group of age-matched patients without a neoplastic disease was used as control cohort. Proteome profiling identified characteristic tumor markers, including F ...[more]