Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human) Plasmodium Vivax
TISSUE(S): Blood Plasma, Extracellular Vesicle
DISEASE(S): Malaria
SUBMITTER: 
Eva Borràs
LAB HEAD: Eduard Sabido
PROVIDER: PXD018337 | Pride | 2020-06-08
REPOSITORIES: Pride
Publications
Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence.
Toda Haruka H Diaz-Varela Miriam M Segui-Barber Joan J Roobsoong Wanlapa W Baro Barbara B Garcia-Silva Susana S Galiano Alicia A Gualdrón-López Melisa M Almeida Anne C G ACG Brito Marcelo A M MAM de Melo Gisely Cardoso GC Aparici-Herraiz Iris I Castro-Cavadía Carlos C Monteiro Wuelton Marcelo WM Borràs Eva E Sabidó Eduard E Almeida Igor C IC Chojnacki Jakub J Martinez-Picado Javier J Calvo Maria M Armengol Pilar P Carmona-Fonseca Jaime J Yasnot Maria Fernanda MF Lauzurica Ricardo R Marcilla Antonio A Peinado Hector H Galinski Mary R MR Lacerda Marcus V G MVG Sattabongkot Jetsumon J Fernandez-Becerra Carmen C Del Portillo Hernando A HA
Nature communications 20200602 1
Plasmodium vivax is the most widely distributed human malaria parasite. Previous studies have shown that circulating microparticles during P. vivax acute attacks are indirectly associated with severity. Extracellular vesicles (EVs) are therefore major components of circulating plasma holding insights into pathological processes. Here, we demonstrate that plasma-derived EVs from Plasmodium vivax patients (PvEVs) are preferentially uptaken by human spleen fibroblasts (hSFs) as compared to the upta ...[more]
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