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Malassezia sympodialis host response studied with an ex-vivo human skin model

ABSTRACT: An ex-vivo human skin model was used to investigate the host skin response to M. sympodialis on oily (supplemented with oleic acid) and non-oily skin. Host-pathogen interactions were analysed by different molecular techniques including proteomics.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Skin

SUBMITTER: David Stead

LAB HEAD: Professor Carol A Munro

PROVIDER: PXD018404 | Pride | 2021-09-09

REPOSITORIES: Pride

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Host Responses in an Ex Vivo Human Skin Model Challenged With Malassezia sympodialis.

Corzo-León Dora E DE MacCallum Donna M DM Munro Carol A CA

Frontiers in cellular and infection microbiology 20210121

Malassezia species are a major part of the normal mycobiota and colonize mainly sebum-rich skin regions of the body. This group of fungi cause a variety of infections such as pityriasis versicolor, folliculitis, and fungaemia. In particular, Malassezia sympodialis and its allergens have been associated with non-infective inflammatory diseases such as seborrheic dermatitis and atopic eczema. The aim of this study was to investigate the host response to M. sympodialis on oily ...[more]

PMID: 33552997

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