Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Plasmodium Falciparum Dd2
SUBMITTER: Joao Paulo
LAB HEAD: Joao A. Paulo
PROVIDER: PXD018718 | Pride | 2020-08-11
REPOSITORIES: Pride
Nature communications 20200715 1
Asexual proliferation of the Plasmodium parasites that cause malaria follows a developmental program that alternates non-canonical intraerythrocytic replication with dissemination to new host cells. We carried out a functional analysis of the Plasmodium falciparum homolog of Protein Phosphatase 1 (PfPP1), a universally conserved cell cycle factor in eukaryotes, to investigate regulation of parasite proliferation. PfPP1 is indeed required for efficient replication, but is absolutely essential for ...[more]