Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Drosophila Melanogaster (fruit Fly) Mus Musculus (mouse)
TISSUE(S): Larva, Embryonic Stem Cell
DISEASE(S): Inherited Metabolic Disorder
SUBMITTER: Florian Schober
LAB HEAD: Anna Wredenberg
PROVIDER: PXD019550 | Pride | 2021-02-22
REPOSITORIES: Pride
Science advances 20210219 8
Induction of the one-carbon cycle is an early hallmark of mitochondrial dysfunction and cancer metabolism. Vital intermediary steps are localized to mitochondria, but it remains unclear how one-carbon availability connects to mitochondrial function. Here, we show that the one-carbon metabolite and methyl group donor <i>S</i>-adenosylmethionine (SAM) is pivotal for energy metabolism. A gradual decline in mitochondrial SAM (mitoSAM) causes hierarchical defects in fly and mouse, comprising loss of ...[more]