Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Claus Scholz
PROVIDER: E-GEOD-51634 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Translational psychiatry 20141021
The serotonin transporter gene (5-HTT/SLC6A4)-linked polymorphic region has been suggested to have a modulatory role in mediating effects of early-life stress exposure on psychopathology rendering carriers of the low-expression short (s)-variant more vulnerable to environmental adversity in later life. The underlying molecular mechanisms of this gene-by-environment interaction are not well understood, but epigenetic regulation including differential DNA methylation has been postulated to have a ...[more]