Dataset Information


Rat intestinal epithelial cells, LC-MS/MS

ABSTRACT: We utilized iTRAQ to detect that rat intestinal mucosa microvascular endothelial cells (RIMVECs) under IL-1α treatment (0, 2, 4, 8h).


ORGANISM(S): Rattus norvegicus  

TISSUE(S): Primary Cell

DISEASE(S): Not Available

SUBMITTER: Xiaoye Liu  

LAB HEAD: Hong Dong

PROVIDER: PXD019561 | Pride | 2021-09-09


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Endothelial-Derived Interleukin-1α Activates Innate Immunity by Promoting the Bactericidal Activity of Transendothelial Neutrophils.

Liu Xiaoye X   Zhang Hui H   He Shangwen S   Mu Xiang X   Hu Ge G   Dong Hong H  

Frontiers in cell and developmental biology 20200707

Migration of neutrophils across endothelial barriers to capture and eliminate bacteria is served as the first line of innate immunity. Bacterial virulence factors damage endothelium to produce inflammatory cytokines interacts with neutrophils. However, the mechanisms that behind endothelial-neutrophil interaction impact on the bactericidal activity remain unclear. Therefore, we aimed to find the target proteins on endothelial cells that triggered the bactericidal activity of transendothelial neu  ...[more]

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