A heme-binding domain in a voltage gated porassium channel
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Waters instrument model
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Primary Cerebral Cortical Neuron�
SUBMITTER: 
Rebekah Jukes-Jones
LAB HEAD: Emma Raven
PROVIDER: PXD019887 | Pride | 2020-09-17
REPOSITORIES: Pride
Publications
Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel.
Burton Mark J MJ Cresser-Brown Joel J Thomas Morgan M Portolano Nicola N Basran Jaswir J Freeman Samuel L SL Kwon Hanna H Bottrill Andrew R AR Llansola-Portoles Manuel J MJ Pascal Andrew A AA Jukes-Jones Rebekah R Chernova Tatyana T Schmid Ralf R Davies Noel W NW Storey Nina M NM Dorlet Pierre P Moody Peter C E PCE Mitcheson John S JS Raven Emma L EL
The Journal of biological chemistry 20200728 38
The EAG (<i>ether-à-go-go</i>) family of voltage-gated K<sup>+</sup> channels are important regulators of neuronal and cardiac action potential firing (excitability) and have major roles in human diseases such as epilepsy, schizophrenia, cancer, and sudden cardiac death. A defining feature of EAG (Kv10-12) channels is a highly conserved domain on the N terminus, known as the eag domain, consisting of a Per-ARNT-Sim (PAS) domain capped by a short sequence containing an amphipathic helix (Cap doma ...[more]
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