Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Hela Cell
SUBMITTER: Nigel Beaton
LAB HEAD: Lukas Reiter
PROVIDER: PXD019902 | Pride | 2020-09-09
REPOSITORIES: Pride
Piazza Ilaria I Beaton Nigel N Bruderer Roland R Knobloch Thomas T Barbisan Crystel C Chandat Lucie L Sudau Alexander A Siepe Isabella I Rinner Oliver O de Souza Natalie N Picotti Paola P Reiter Lukas L
Nature communications 20200821 1
Chemoproteomics is a key technology to characterize the mode of action of drugs, as it directly identifies the protein targets of bioactive compounds and aids in the development of optimized small-molecule compounds. Current approaches cannot identify the protein targets of a compound and also detect the interaction surfaces between ligands and protein targets without prior labeling or modification. To address this limitation, we here develop LiP-Quant, a drug target deconvolution pipeline based ...[more]