Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Plasmodium Falciparum
TISSUE(S): Erythrocyte
DISEASE(S): Plasmodium Falciparum Malaria
SUBMITTER: Virginie Salnot
LAB HEAD: Gwladys Bertin
PROVIDER: PXD020052 | Pride | 2021-02-10
REPOSITORIES: Pride
Kamaliddin Claire C Guillochon Emilie E Salnot Virginie V Rombaut David D Huguet Stéphanie S Guillonneau François F Houzé Sandrine S Cot Michel M Deloron Philippe P Argy Nicolas N Bertin Gwladys I GI
Journal of proteome research 20210121 2
<i>Plasmodium falciparum</i> is the main causative agent of human malaria. During the intraerythrocytic development cycle, the <i>P. falciparum</i> morphology changes dramatically from circulating young rings to sequestered mature trophozoites and schizonts. Sequestered forms contribute to the pathophysiology of severe malaria as the infected erythrocytes obstruct the microvascular flow in deep organs and induce local inflammation. However, the sequestration mechanism limits the access to the co ...[more]