Identification of a subtelomeric gene family expressed during the asexual-sexual stage transition in Plasmodium falciparum

ABSTRACT: For malaria transmission, the parasite must undergo sexual differentiation into mature gametocytes. However, the molecular basis for this critical transition in the parasites life cycle is unknown. Six previously uncharacterized genes, Pfg14.744, Pfg14.745, Pfg14.748, Pfg14.763, Pfg14.752 and Pfg6.6 that are members of a 36 gene Plasmodium falciparum-specific subtelomeric superfamily were found to be expressed in parasites that are committed to sexual development as suggested by co-expression of Pfs16 and Pfg27. Northern blots demonstrated that Pfg14.744 and Pfg14.748 were first expressed before the parasites differentiated into morphologically distinct gametocytes, transcription continued to increase until stage II gametocytes were formed and then rapidly decreased. Immunofluorescence ass

ORGANISM(S): Plasmodium falciparum

SUBMITTER: Tetsuya Furuya 

PROVIDER: E-GEOD-62364 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress