Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Ovary
DISEASE(S): Malignant Neoplasm Of Ovary
SUBMITTER: Melissa Bradbury
LAB HEAD: Eduard Sabidó
PROVIDER: PXD020271 | Pride | 2022-04-04
REPOSITORIES: Pride
Bradbury Melissa M Borràs Eva E Castellví Josep J Méndez Olga O Sánchez-Iglesias José Luis JL Pérez-Benavente Assumpció A Gil-Moreno Antonio A Sabidó Eduard E Santamaria Anna A
Scientific reports 20220315 1
Despite recent advances in the management of BRCA1 mutated high-grade serous ovarian cancer (HGSC), the physiology of these tumors remains poorly understood. Here we provide a comprehensive molecular understanding of the signaling processes that drive HGSC pathogenesis with the addition of valuable ubiquitination profiling, and their dependency on BRCA1 mutation-state directly in patient-derived tissues. Using a multilayered proteomic approach, we show the tight coordination between the ubiquiti ...[more]