Neuronal cells from ASL patients

ABSTRACT: This study describes altered CREB-dependent activity related transcription, and disrupted synaptic composition as common pathological features in ALS. These aberrations are restored by Apamin and XE991, two K+ channel blockers targeting the SK and Kv7 channels and modulating neuronal excitability.This study describes altered CREB-dependent activity related transcription, and disrupted synaptic composition as common pathological features in ALS. These aberrations are restored by Apamin and XE991, two K+ channel blockers targeting the SK and Kv7 channels and modulating neuronal excitability.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Multipotent Stem Cell, Cotyledon

SUBMITTER: Chiara guerrera  

LAB HEAD: GUERRERA Isa Chuara

PROVIDER: PXD020316 | Pride | 2021-05-11

REPOSITORIES: Pride