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The protein possibly interacting with TRIB2 in Bel-7402 cells

ABSTRACT: Bound materials that immunoprecipitated by anti-TRIB2 in Bel-7402 cells was extracted and separated using SDS-PAGE electrophoresis. MS analysis was performed and protein was identified and quantified using MASCOT 2.4.1 server using the Swiss-Prot database.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Liver

SUBMITTER: zhang xiao

LAB HEAD: zhang xiao,

PROVIDER: PXD020325 | Pride | 2021-09-09

REPOSITORIES: Pride

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TRIB2 modulates proteasome function to reduce ubiquitin stability and protect liver cancer cells against oxidative stress.

Guo Susu S Chen Yuxin Y Yang Yueyue Y Zhang Xiao X Ma Lifang L Xue Xiangfei X Qiao Yongxia Y Wang Jiayi J

Cell death & disease 20210107 1

The regulation of homeostasis in the Ubiquitin (Ub) proteasome system (UPS) is likely to be important for the development of liver cancer. Tribbles homolog 2 (TRIB2) is known to affect Ub E3 ligases (E3s) in liver cancer. However, whether TRIB2 regulates the UPS in other ways and the relevant mechanisms are still unknown. Here, we reveal that TRIB2 decreased Ub levels largely by stimulating proteasome degradation of Ub. In the proteasome, proteasome 20S subunit beta 5 (PSMB5) was critical for th ...[more]

PMID: 33414446

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