Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 6600
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Tendon
SUBMITTER: Rosalind Jenkins
LAB HEAD: Rosalind E Jenkins
PROVIDER: PXD020374 | Pride | 2022-09-28
REPOSITORIES: Pride
Ide Kentaro K Takahashi Sanai S Sakai Keiko K Taga Yuki Y Ueno Tomonori T Dickens David D Jenkins Rosalind R Falciani Francesco F Sasaki Takako T Ooi Kazuhiro K Kawashiri Shuichi S Mizuno Kazunori K Hattori Shunji S Sakai Takao T
The Journal of biological chemistry 20210523 1
Collagen-derived hydroxyproline (Hyp)-containing peptides have a variety of biological effects on cells. These bioactive collagen peptides are locally generated by the degradation of endogenous collagen in response to injury. However, no comprehensive study has yet explored the functional links between Hyp-containing peptides and cellular behavior. Here, we show that the dipeptide prolyl-4-hydroxyproline (Pro-Hyp) exhibits pronounced effects on mouse tendon cells. Pro-Hyp promotes differentiatio ...[more]