Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Drosophila Melanogaster (fruit Fly)
TISSUE(S): Cell Culture
SUBMITTER: Bridget Lear
LAB HEAD: Ravi Allada
PROVIDER: PXD020986 | Pride | 2020-11-11
REPOSITORIES: Pride
Kula-Eversole Elżbieta E Lee Da Hyun DH Samba Ima I Yildirim Evrim E Levine Daniel C DC Hong Hee-Kyung HK Lear Bridget C BC Bass Joseph J Rosbash Michael M Allada Ravi R
Current biology : CB 20201105 1
The timing of behavior under natural light-dark conditions is a function of circadian clocks and photic input pathways, but a mechanistic understanding of how these pathways collaborate in animals is lacking. Here we demonstrate in Drosophila that the Phosphatase of Regenerating Liver-1 (PRL-1) sets period length and behavioral phase gated by photic signals. PRL-1 knockdown in PDF clock neurons dramatically lengthens circadian period. PRL-1 mutants exhibit allele-specific interactions with the l ...[more]