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Regional identity of human neural stem cells determinesoncogenic responses to histone 1H3.3 mutants

ABSTRACT: Regional identity of human neural stem cells determinesoncogenic responses to histone 1H3.3 mutants

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Neuronal Stem Cell

DISEASE(S): Brain Glioma

SUBMITTER: Jimi Wills

LAB HEAD: Steven M Pollard

PROVIDER: PXD021270 | Pride | 2021-09-09

REPOSITORIES: Pride

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Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants.

Bressan Raul Bardini RB Southgate Benjamin B Ferguson Kirsty M KM Blin Carla C Grant Vivien V Alfazema Neza N Wills Jimi C JC Marques-Torrejon Maria Angeles MA Morrison Gillian M GM Ashmore James J Robertson Faye F Williams Charles A C CAC Bradley Leanne L von Kriegsheim Alex A Anderson Richard A RA Tomlinson Simon R SR Pollard Steven M SM

Cell stem cell 20210224 5

Point mutations within the histone H3.3 are frequent in aggressive childhood brain tumors known as pediatric high-grade gliomas (pHGGs). Intriguingly, distinct mutations arise in discrete anatomical regions: H3.3-G34R within the forebrain and H3.3-K27M preferentially within the hindbrain. The reasons for this contrasting etiology are unknown. By engineering human fetal neural stem cell cultures from distinct brain regions, we demonstrate here that cell-intrinsic regional identity provides differ ...[more]

PMID: 33631116

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