Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Epithelial Cell Of Small Intestine, Intestine
SUBMITTER: Roberta Noberini
LAB HEAD: Tiziana Bonaldi
PROVIDER: PXD022171 | Pride | 2021-01-11
REPOSITORIES: Pride
Nucleic acids research 20210101 2
The proteolytic cleavage of histone tails, also termed histone clipping, has been described as a mechanism for permanent removal of post-translational modifications (PTMs) from histone proteins. Such activity has been ascribed to ensure regulatory function in key cellular processes such as differentiation, senescence and transcriptional control, for which different histone-specific proteases have been described. However, all these studies were exclusively performed using cell lines cultured in v ...[more]