Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell
SUBMITTER: Georg Tascher
LAB HEAD: Xinlai Cheng
PROVIDER: PXD022199 | Pride | 2022-10-18
REPOSITORIES: Pride
Gama-Brambila Rodrigo A RA Chen Jie J Dabiri Yasamin Y Tascher Georg G Němec Václav V Münch Christian C Song Guangqi G Knapp Stefan S Cheng Xinlai X
JACS Au 20210512 6
The discovery of clustered regularly interspaced short palindromic repeats and their associated proteins (Cas) has revolutionized the field of genome and epigenome editing. A number of new methods have been developed to precisely control the function and activity of Cas proteins, including fusion proteins and small-molecule modulators. Proteolysis-targeting chimeras (PROTACs) represent a new concept using the ubiquitin-proteasome system to degrade a protein of interest, highlighting the signific ...[more]