Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Epithelial Cell, Intestinal Epithelial Cell
DISEASE(S): Type 2 Diabetes Mellitus
SUBMITTER: Anil Kumar
LAB HEAD: Huang-Ge Zhang
PROVIDER: PXD022641 | Pride | 2021-03-23
REPOSITORIES: Pride
Nature communications 20210111 1
High-fat diet (HFD) decreases insulin sensitivity. How high-fat diet causes insulin resistance is largely unknown. Here, we show that lean mice become insulin resistant after being administered exosomes isolated from the feces of obese mice fed a HFD or from patients with type II diabetes. HFD altered the lipid composition of exosomes from predominantly phosphatidylethanolamine (PE) in exosomes from lean animals (L-Exo) to phosphatidylcholine (PC) in exosomes from obese animals (H-Exo). Mechanis ...[more]