Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus
ORGANISM(S): Xenopus Laevis (african Clawed Frog)
TISSUE(S): Oocyte
SUBMITTER: Laurent Lignières
LAB HEAD: Guillaume Chevreux
PROVIDER: PXD022739 | Pride | 2021-03-12
REPOSITORIES: Pride
Nature communications 20210323 1
Oocytes are held in meiotic prophase for prolonged periods until hormonal signals trigger meiotic divisions. Key players of M-phase entry are the opposing Cdk1 kinase and PP2A-B55δ phosphatase. In Xenopus, the protein Arpp19, phosphorylated at serine 67 by Greatwall, plays an essential role in inhibiting PP2A-B55δ, promoting Cdk1 activation. Furthermore, Arpp19 has an earlier role in maintaining the prophase arrest through a second serine (S109) phosphorylated by PKA. Prophase release, induced b ...[more]